Priya Ranjan Debata

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EXPERTISE INFORMATION

Research Group

Areas of Interest

Molecular Pathology and Biomarker Analysis in Human Gliomas, Cell cycle progression, 3.Tumor Angiogenesis and Growth Factor Signaling Pathways, 4.Natural compounds and anticancer therapeutics

Dr. Priya Ranjan Debata

Assistant Professor - III, Zoology

M.Sc., Ph.D.

prdebata@gmail.com

Biosketch

8847870334

31
Publications
45
Google Scholar
19
Research Scholars
9
Courses Taught
PERSONAL INFORMATION

Dr. Priya Ranjan Debata is an academician and researcher in the field of zoology and biomedical sciences with a strong focus on cancer biology. His research primarily investigates the molecular mechanisms underlying tumor development and progression, with particular emphasis on glioma and other brain tumors.
A significant aspect of Dr. Debata’s research explores the role of altered cellular metabolism in cancer. He is interested in understanding how metabolic reprogramming supports tumor growth and survival, and how these metabolic changes interact with oncogenic signaling pathways. His work also examines the role of key signaling molecules involved in regulating tumor cell proliferation, angiogenesis, and invasion.

Another important area of his research involves the study of cell cycle regulatory proteins and their dysregulation in cancer progression. Through the use of molecular and immunohistochemical approaches, Dr. Debata investigates the expression patterns of various tumor markers and signaling proteins in different grades of glioma, including glioblastoma. This research contributes to understanding the molecular events that drive malignant transformation and tumor aggressiveness.

Dr. Debata is also interested in the therapeutic potential of natural compounds in cancer treatment. His studies explore how bioactive molecules derived from natural sources may influence signaling pathways, regulate cell cycle checkpoints, and induce anti-tumor effects. This line of research aims to identify safer and more effective therapeutic strategies for cancer management.
Through his teaching and research activities, Dr. Debata continues to contribute to advancing knowledge in cancer biology, particularly in the areas of tumor metabolism, molecular signaling, and translational approaches for glioma therapy.

Journals:

  • Kumar D, Basu S, Parija L, Rout D, Manna S, Dandapat J, Debata PR. Curcumin and Ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cells. Biomed and Pharma. 2016 (81) 31-37
  • Punia A, Debata PR, Banerjee P, Yang NL. Structure–property relationships of antibacterial amphiphilic polymers derived from 2aminoethyl acrylate. RSC Advances. 2015 Oct 5 (115), 95300-95306
  • Castellanos MR, Szerszen A, Gundry S, Pirog EC, Maiman M, Rajupet S, Gomez JP, Davidov A, Debata PR, Banerjee P, Fata JE. Diagnostic imaging of cervical intraepithelial neoplasia based on hematoxylin and eosin fluorescence. Diagn Pathol. 2015 Jul 25;10(1):119.
  • Langone P, Debata PR*, Inigo Jdel R, Dolai S, Mukherjee S, Halat P, Mastroianni K, Curcio GM, Castellanos MR, Raja K, Banerjee P. Coupling to a glioblastoma-directed antibody potentiates antitumor activity of curcumin. Int J Cancer. 2014 Aug 1;135(3):710-9. (* Equal first authorship)
  • Debata PR, Begum S, Mata A, Genzer O, Kleiner MJ, Banerjee P, Castellanos MR. Curcumin potentiates the ability of sunitinib to eliminate the VHL-lacking renal cancer cells 786-O: rapid inhibition of Rb phosphorylation as a preamble to cyclin D1 inhibition. Anticancer Agents Med Chem. 2013 Dec;13(10):1508-13.
  • Debata PR, Castellanos MR, Fata JE, Baggett S, Rajupet S, Szerszen A, Begum S, Mata A, Murty VV, Opitz LM, Banerjee P. A novel curcumin-based vaginal cream Vacurin selectively eliminates apposed human cervical cancer cells. Gynecol Oncol. 2013 Apr;129(1):145-53.
  • Mogha A, Guariglia SR, Debata PR, Wen GY, Banerjee P. Serotonin 1A receptor-mediated signaling through ERK and PKCα is essential for normal synaptogenesis in neonatal mouse hippocampus. Transl Psychiatry. 2012 Jan 10;2:e66.
  • Levano K, Punia V, Raghunath M, Debata PR, Curcio GM, Mogha A, Purkayastha S, McCloskey D, Fata J, Banerjee P. Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning. J Neurochem. 2012 Jan;120(2):302-13.
  • Langone P, Debata PR*, Dolai S, Curcio GM, Inigo Jdel R, Raja K, Banerjee P. Coupling to a cancer cell-specific antibody potentiates tumoricidal properties of curcumin. Int J Cancer. 2012 Aug 15;131(4):E569-78. (* Equal first authorship)
  • Debata PR, Ranasinghe B, Berliner A, Curcio GM, Tantry SJ, Ponimaskin E, Banerjee P. Erk1/2-dependent phosphorylation of PKCalpha at threonine 638 in hippocampal 5-HT(1A) receptor-mediated signaling. Biochem Biophys Res Commun. 2010 Jul 2;397(3):401-6.

Book Chapters

  • Debata P.R., Curcio G.M., Mukherjee S., Banerjee P. (2014), Causal factors for brain tumor and targeted strategies, in Universe of Scales: From Nanotechnology to Cosmology, Springer International Publishing, pp 191–204
  • Samaddar S., Ranasinghe B., Tantry S.J., Debata P.R., Banerjee P. (2015), Role of VEGF in serotonin 1A receptor-mediated neuroproliferation in neonatal mouse hippocampus, Advances in Experimental Medicine and Biology, Vol. 842, pp 375–388, Springer
  • Pani S., Debata P.R. (2018), Bioactive phytocompounds for treatment of HPV-mediated cervical cancer, in Health Sciences: Basic Research Approaches, ISBN: 817019604-2, pp 21–24
  • Hansdah S., Mohapatra S., Debata P.R. (2019), Anti-cancer properties of medicinal plants in human glioma cells (T98G), in Biotechnology for Sustainable Utilization of Bioresources, Daya Publishing House, New Delhi, pp 249–256, ISBN: 978-93-88982-00-9

  • Ph.D – 2008 – Institute of Life Sciences (Utkal University)

  • Assistant Professor, Maharaja Sriram Chandra Bhanja Deo University — 12 years
  • Ramalingaswami Re-entry Fellow, Utkal University, Bhubaneswar — 1.5 years
  • Postdoctoral Research Associate, City University of New York, USA — 5.8 years

  • Ramalingaswami Research Fellowship-2012-13 of Department of Biotechnology (DBT), Government of India
  • Qualified national level examination of CSIR-JRF-NET -2001 and recipient of both junior and senior research fellowships from Council of Scientific and Industrial Research (CSIR), New Delhi

  • ZO-103, Physiology and Endocrinology, 2025
  • ZO-106, Indian Knowledge System, 2025
  • ZO-105, Practical, 2025
  • ZO-203, Biostatistics, Techniques and Tools in Biology, 2026
  • ZO-205, Practical, 2026
  • ZO-303, Biochemistry, 2025
  • ZO-304, Practical, 2025
  • ZO-401, Chordata, Comparative Anatomy, Evolution and Animal Behavior, 2026
  • ZO-403, Practical, 2026

  • To characterize a novel topical cream therapy against cervical cancer and target tumor microenvironment — DBT, Govt. of India — Amount: 32.5 Lakh — Duration: 5 Years (04 July 2013 – 03 July 2018) — Status: Completed
  • Study on frequency distribution of mutated IDH1/2 in glioma patients of Odisha and its role in cellular metabolism — DST, Govt. of Odisha — Amount: 10 Lakh — Duration: 3 Years (2018–2021) — Status: Completed
  • Identification of genetic/epigenetic markers in cervical carcinogenesis for precision medicine — DST, Govt. of India & BRICS — Amount: 9.8 Lakh — Duration: 3 Years (Started: 10 April 2018) — Status: Completed
  • Elucidating metabolic alterations in glioma cells using CRISPR-Cas mediated IDH1/2 mutagenesis (U87/T98 cells) — Dept. of Higher Education, Govt. of Odisha (MRIP-2023) — Amount: 10 Lakh — Duration: 2 Years — Status: Completed

  • Ph.D., Screening, isolation and characterization of selected plants from Northern Odisha for anticancer properties in glioblastoma, Ms. Shubhasmita Mohapatra, Enrolled: 2016, Graduated: 2021, Supervisor
  • Ph.D., Effect of phytocompounds on modulation of tumor microenvironment in melanoma, Ms. Sarita Pani, Enrolled: 2016, Graduated: 2022, Supervisor
  • Ph.D., Behavior of modal ecorace of Antheraea mylitta in Similipal Biosphere Reserve, Ms. Arati Bala Sahu, Enrolled: 2016, Graduated: 2021, Supervisor
  • Ph.D., Role of altered carbohydrate metabolism linked with IDH1/2 mutation in glioma, Ms. Amrita Sahoo, Enrolled: 2016, Graduated: 2024, Supervisor
  • Ph.D., Effects of synthetic and phytocompounds in modulation of signalling pathways in glioma cells, Ms. Sunitee Hansdah, Enrolled: 2017, Graduated: 2025, Supervisor
  • Ph.D., Expression of EGFR and associated signalling in glioma patients of Odisha, Ms. Swati Sucharita Panda, Enrolled: 2021, Graduated: Ongoing, Supervisor
  • Ph.D., Aberrant signalling associated with P53 mutation in glioma cells, Ms. Subhalaxmi Pattanayak, Enrolled: 2023, Graduated: Ongoing, Supervisor
  • Ph.D., Role of mutant IDH1 gene in metabolic reprogramming and cell cycle in glioma, P.B. Anuradha Swain, Enrolled: 2024, Graduated: Ongoing, Supervisor
  • M.Phil., Anti-cancer properties of medicinal plants in human glioma cells (T98G), Sunitee Hansdah, Enrolled: 2014, Graduated: 2015, Supervisor
  • M.Phil., Curcumin and ellagic acid mediated ROS generation and cell death in HeLa cells, Budhadev Baral, Enrolled: 2015, Graduated: 2016, Supervisor
  • M.Phil., Anticancer property of curcumin, quercetin, ellagic acid in HeLa cells, Abhilipsa Patra, Enrolled: 2015, Graduated: 2016, Supervisor
  • M.Phil., Anti-cancer properties of gardiquimod, curcumin, resveratrol in HeLa cells, Abhipsa Shatarupa, Enrolled: 2015, Graduated: 2016, Supervisor
  • M.Phil., Megaselia scalaris as model organism for aging research, Deepika Rana, Enrolled: 2016, Graduated: 2017, Supervisor
  • M.Phil., Ethanolic extract of Justicia adhatoda for lifespan extension in Megaselia scalaris, Sushreeta Das, Enrolled: 2017, Graduated: 2018, Supervisor
  • M.Phil., Dipyromethane compounds for anticancer properties in HeLa cells, Kabita Khuntia, Enrolled: 2018, Graduated: 2019, Supervisor
  • M.Phil., Anti-angiogenic effect of phytocompounds using chick chorioallantois membrane model, Samiran Behera, Enrolled: 2019, Graduated: 2020, Supervisor
  • M.Phil., Anti-angiogenic activity of phytocompounds in CAM model, Shubhalakshmi Pattanayak, Enrolled: 2020, Graduated: 2021, Supervisor
  • M.Phil., Survey and documentation of small fish population in Baripada, Mayurbhanj, Odisha, Sunil Rout, Enrolled: 2021, Graduated: 2022, Supervisor

  • Life Member, Society for Biotechnologists (India) (SBTI) — L693
  • Life Member, Indian Science Congress Association
  • Life Member, Zoological Society of Odisha

  • Deputy Director Incubation Centre – 2020
  • Deputy Director IQAC – 2020
  • Nodal Officer NIRF – 2024